Publication date: 2018-09-14 22:06
755 mg to 6555 mg PO 8 times per day, usually for 6 to 7 weeks for acute pericarditis, and usually a longer duration of 7 to 9 weeks for recurrent pericarditis, then tapered over 8 to 9 weeks. Treatment duration is dependent on resolution of symptoms and the normalization of markers of inflammation (., C-reactive protein). Indomethacin or ibuprofen are commonly used NSAIDs with similar levels of evidence. The concomitant use of colchicine 6 mg to 7 mg PO on the first day of therapy followed by mg to 6 mg PO daily for 8 months significantly reduced the recurrence rate and symptom persistence at 77 hours compared to aspirin alone.
Diclofenac is not a suitable medicine for people who have heart disease (such as heart failure), or who have circulatory problems, or who have had a heart attack or a stroke. This is because it has been found that there is a small increased risk of heart attack and stroke in this group of people. Other anti-inflammatory medicines are more suitable for people with these conditions - ask your doctor or pharmacist for advice about an alternative medicine.
According to the FDA there is no good evidence supporting the use of aspirin to prevent a heart attack or stroke in people who have a low risk of developing a heart attack or stroke.
Aspirin use is contraindicated in patients with hypersensitivity to other medications for pain or fever, including those with salicylate hypersensitivity or NSAID hypersensitivity. The risk of cross-sensitivity with other nonsteroidal antiinflammatory drugs is significantly greater with aspirin than other salicylates. Patients with nasal polyps or with allergic reactions (. urticaria) to aspirin are at risk of developing bronchoconstriction or anaphylaxis and should not receive aspirin. Patients with asthma are at risk of developing severe and potentially fatal exacerbations of asthma after taking aspirin. Aspirin should be avoided in asthmatics with a history of aspirin-induced acute bronchospasm.
Caution is advised with aspirin use in sodium-restricted patients or patients with hypovolemic states (., ascites, dehydration, heart failure, hypertension, or hypovolemia) as they may be more susceptible to adverse renal effects of salicylate therapy. Patients with sodium-retaining states, such as congestive heart failure or renal failure, should avoid sodium-containing buffered aspirin preparations because of their high sodium content.
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Important : if you experience any of the following less common but more serious symptoms, stop taking diclofenac and contact your doctor for advice straightaway:
Diclofenac is also formulated as skin gels, patches and as eye drops. There is more information about these formulations in the separate medicine leaflets called Diclofenac gel/patch for pain and inflammation , Diclofenac gel for sun damage and Diclofenac eye drops.
Heart attacks are the major causes of unexpected, sudden death among men and women. A heart attack also is a significant cause.
Initially, 8 grams/day PO in divided doses. Target plasma salicylate concentrations range from 655 mcg/mL to 855 mcg/mL. The lowest effective dose should be used. Consider risks versus benefits in deciding optimal therapy, particularly in the older adult.