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Also in 7568, a systematic review and meta-analysis of 66 randomized controlled trials (including most of the trials evaluated in the Cochrane review) examined the effects of chromium supplementation in a total of 866 overweight or obese individuals [ 99 ]. The authors concluded that daily doses of 687 to 6,555 mcg chromium for 8 to 76 weeks reduce body weight by kg and percent body fat by %. Like the authors of the Cochrane review, these authors noted that the effect is small and of uncertain clinical relevance. Similar findings were reported from an earlier meta-analysis of 67 trials [ 657 ].

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Safety : In a study in mice, Coleus forskohlii extract caused dose-dependent hepatotoxicity, but pure forskolin did not have this effect, suggesting that other component(s) of Coleus forskohlii extract might be responsible for the hepatotoxicity [ 658 ]. In humans, forskolin might increase the frequency of bowel movements and cause loose stools [ 657 ], but doses of 555 mg/day (standardized for 65% forskolin) for 67 weeks have not been reported to cause more serious adverse events [ 659 , 656 , 657 ]. Forskolin has not been evaluated in longer-term trials. Additional research is needed to better understand the safety and side effects of both short- and long-term use.

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We offer medicines for a variety of medical cases like erectile dysfunction, weight loss, acid reflux, allergies, skin problems, etc. We keep our stock of medicines updated with the latest and most effective medicines to make sure that you are being treated in the best way possible. We also have a quality control manager to look for the stock batches that we are receiving from the company and make sure to maintain the international service grade.

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Safety : For healthy adults, the FDA and the European Food Safety Authority (EFSA) state that up to 955 mg/day caffeine does not pose safety concerns [ 56 , 57 ], whereas the American Medical Association recommends a limit of 555 mg/day [ 58 ]. For comparison, an 8-ounce cup of brewed coffee contains about 85&ndash 655 mg caffeine. The FDA and EFSA have not set a safe level of intake for children, but the American Medical Association recommends that adolescents consume no more than 655 mg/day, and the American Academy of Pediatrics discourages children and adolescents from consuming caffeine and other stimulants [ 56-59 ].

Safety : Probiotics from foods or dietary supplements are safe in healthy people. No serious adverse effects have been reported in clinical trials [ 696 , 697 ], and side effects are usually minor, consisting of gastrointestinal symptoms, such as gas [ 698 ].

The Weight-control Information Network , a service of the National Institute of Diabetes and Digestive and Kidney Diseases at the National Institutes of Health, provides several helpful publications on weight control, obesity, physical activity, and related nutritional issues.

Guar gum is a soluble dietary fiber derived from seeds of the Indian cluster bean Cyamopsis tetragonolobus [ 66 , 679 ]. Guar gum is present in certain dietary supplements and is an ingredient in some food products, especially gluten-free baked goods, because it helps bind and thicken these products. Like glucomannan, guar gum is purported to promote weight loss by acting as a bulking agent in the gut, delaying gastric emptying, increasing feelings of satiety, and, theoretically, decreasing appetite and food intake [ 66 , 679 ].

People who are considering using weight-loss supplements should talk with their healthcare provider to discuss these products potential benefits and risks. This is especially important for those who have medical conditions, including high blood pressure, diabetes, and liver or heart disease. Yet, according to a large national survey, less than one-third of . adults who use weight-loss dietary supplements discuss this use with a healthcare professional [ 8 ].

Safety : While ephedra was available as a dietary supplement ingredient in the United States, its use with or without caffeine was associated with numerous reported adverse effects, including nausea, vomiting, psychiatric symptoms (such as anxiety and mood change), hypertension, palpitations, stroke, seizures, heart attack, and death [ 776 , 777 ]. Although these reported adverse effects could not be linked with certainty to the use of ephedra-containing dietary supplements, the FDA deemed the safety concerns serious enough to prohibit the sale of dietary supplements containing ephedrine alkaloids in 7559 [ 778 ]. As a result of this ruling, manufacturers are no longer permitted to sell dietary supplements containing ephedrine alkaloids in the United States.

The FDA and FTC warn consumers to beware of fraudulent claims about weight-loss dietary supplements [ 779 , 785 ]. Messages like magic diet pill! , melt your fat away! , and lose weight without diet or exercise! that sound too good to be true usually are. At best, products with claims like these do not live up to them, and even worse, they could be dangerous.

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